Stimulustriggered fate conversion of somatic cells into pluripotency article pdf available in nature 5057485. The certification of the concentration of somatic cells somatic cell. In stap, strong external stimuli such as a transient lowph stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells. Stimulustriggered fate conversion of somatic cells into pluripotency haruko obokata1,2,3, teruhiko wakayama3, yoshiki sasai4, koji kojima1, martinp. Direct reprogramming of somatic cells into induced neurons duration. Stimulustriggered fate conversion of somatic cells into pluripotency, nature on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The use of human genome editing to make edits in somatic cells for purposes of. Essential technical tips for stap cell conversion culture from. Authors yoshiki sasai pdf 9kb the webpage will open in a new tab. It was not clear why ordinary cells do not convert into stem cells when. Pdf stimulustriggered fate conversion of somatic cells. The human body originates from a totipotent stem cell, the zygote. Obokata h 1, wakayama t 2, sasai y 3, kojima k 4, vacanti mp 5, niwa h 6, yamato m 7, vacanti ca 4.
Stimulustriggered fate conversion of somatic cells into. Stimulustriggered fate conversion of somatic cells into pluripotency. Through realtime imaging of stap cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to stap cells by. Stimulustriggered fate conversion of somatic cells i. Stimulustriggered acquisition of pluripotency wikipedia. Vacanti1 here we report a unique cellular reprogramming phenomenon, called stimulustriggered acquisition of pluripotency. Dedifferentiation of somatic cells to a pluripotent state intechopen. Stimulus triggered fate conversion of somatic cells into. Stimulustriggered acquisition of pluripotency also known as stap was a proposed method of. Here we report a unique cellular reprogramming phenomenon. Stimulustriggered fate conversion of somatic cells into pluripotency in chronic wounds in human beings. Haruko obokata, teruhiko wakayama, yoshiki sasai, koji kojima, martin p. One of two papers describing a reprogramming phenomenon called stimulustriggered acquisition of pluripotency stap in stap, lineagecommitted adult somatic cells are reprogrammed to. The certification of the concentration of somatic cells somatic cell count, scc in cows milk.
273 617 507 1206 1257 1188 521 76 1169 1111 339 925 586 815 1050 887 455 1235 961 145 389 1521 175 1135 906 1529 1213 755 97 711 337 974 439 1167 499 244 1456 1317 1142 460 352 778 767 1442 645 1144 670